Synthesis and antiviral activity of carbocyclic nucleosides incorporating a modified cyclopentane ring. Part 3: Adenosine and uridine analogues.

Authors
Nieto, MI Blanco, JM Caamano, O Fernandez, F Garcia-Mera, X Lopez, C Balzarini, J De Clercq, E
Citation
Mi. Nieto et al., Synthesis and antiviral activity of carbocyclic nucleosides incorporating a modified cyclopentane ring. Part 3: Adenosine and uridine analogues., NUCLEOS NUC, 18(10), 1999, pp. 2253-2263
Citations number
15
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
10
Year of publication
1999
Pages
2253 - 2263
Database
ISI
SICI code
0732-8311(1999)18:10<2253:SAAAOC>2.0.ZU;2-1
Abstract
Six new carbocyclic nucleosides were prepared by mounting a purine (compoun ds 4-6), 8-azapurine (7 and 8) or uridine (9) base on the amino group of (1 S,3R)-3-amino-2,2,3-trimethylcyclopentylmethanol (10). At subtoxic concentr ations, compounds 5-9 showed at best marginal antiviral activity.