N-3-beta-D-glucopyranosyl, galactopyranosyl and xylopyranosyl 6-methyl-2-me
thylthiouracil and their 5-bromo derivatives have been synthesized by coupl
ing an alpha-acetobromosugar with the corresponding thiouracil. The new mod
ified thiouridine analogues were evaluated for their inhibitory activity ag
ainst Human Immunodeficiency Virus (HIV) replication in MT-4 cells as well
as for their cytotoxicity.