Synthesis and biological activity of modified thiopyrimidine nucleosides

Authors
Attia, AM Sallam, MA Almehdi, AA Abbasi, MM
Citation
Am. Attia et al., Synthesis and biological activity of modified thiopyrimidine nucleosides, NUCLEOS NUC, 18(10), 1999, pp. 2307-2315
Citations number
13
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
10
Year of publication
1999
Pages
2307 - 2315
Database
ISI
SICI code
0732-8311(1999)18:10<2307:SABAOM>2.0.ZU;2-H
Abstract
N-3-beta-D-glucopyranosyl, galactopyranosyl and xylopyranosyl 6-methyl-2-me thylthiouracil and their 5-bromo derivatives have been synthesized by coupl ing an alpha-acetobromosugar with the corresponding thiouracil. The new mod ified thiouridine analogues were evaluated for their inhibitory activity ag ainst Human Immunodeficiency Virus (HIV) replication in MT-4 cells as well as for their cytotoxicity.