Utilization of tetrabutylammonium triphenyldifluorosilicate (TBAT) in the synthesis of 6-fluoropurine nucleosides

Authors
Gurvich, V Kim, HY Hodge, RP Harris, CM Harris, TM
Citation
V. Gurvich et al., Utilization of tetrabutylammonium triphenyldifluorosilicate (TBAT) in the synthesis of 6-fluoropurine nucleosides, NUCLEOS NUC, 18(10), 1999, pp. 2327-2333
Citations number
15
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
10
Year of publication
1999
Pages
2327 - 2333
Database
ISI
SICI code
0732-8311(1999)18:10<2327:UOTT(I>2.0.ZU;2-3
Abstract
Tetrabutylammonium triphenydifluorosilicate (TBAT) has been found to be a u seful reagent for the conversion of 6-chloropurine nucleosides to 6-fluorop urine derivatives. The 6-chloropurine nucleosides were reacted with trimeth ylamine to form quaternary trimethylammonium salts which were treated in si tu with TBAT in DMF to effect conversion to the 6-fluoro derivatives in yie lds of 59-72%.