Progestin regulation in tumor growth of female genital tract cancers

Authors
Fujimoto, J Sakaguchi, H Misao, R Hirose, R Wen, HW Tamaya, T
Citation
J. Fujimoto et al., Progestin regulation in tumor growth of female genital tract cancers, ONCOL-BASEL, 57, 1999, pp. 59-63
Citations number
53
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
ONCOLOGY
ISSN journal
00302414 → ACNP
Volume
57
Year of publication
1999
Supplement
2
Pages
59 - 63
Database
ISI
SICI code
0030-2414(1999)57:<59:PRITGO>2.0.ZU;2-4
Abstract
The irregular response to progestins directly in tumor growth might be caus ed by dominant negative progesterone receptor (PR) mutants and the damage t o PR-A expression, Progestin treatment as an anti-angiogenic therapy would be less effective in the PR-mutated tumors, Therefore, various anti-angioge nic inhibitors must be used in progestin-refractory and progestin-dependent tumors.