Dd. Price et al., An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm, PAIN, 83(2), 1999, pp. 147-156
Placebo analgesia was produced by conditioning trials wherein heat induced
experimental pain was surreptitiously reduced in order to test psychologica
l factors of expectancy and desire for pain reduction as possible mediators
of placebo analgesia. The magnitudes of placebo effects were assessed afte
r these conditioning trials and during trials wherein stimulus intensities
were reestablished to original baseline levels. In addition, analyses were
made of the influence of these psychological factors on concurrently assess
ed pain and remembered pain intensities. Statistically reliable placebo eff
ects on sensory and affective measures of pain were graded according to the
extent of surreptitious lowering of stimulus strength during the manipulat
ion trials, consistent with conditioning. However, all of these effects wer
e strongly associated with expectancy but not desire for relief. These resu
lts show that although conditioning may be sufficient for placebo analgesia
, it is likely to be mediated by expectancy. The results further demonstrat
ed that placebo effects based on remembered pain were 3 to 4 times greater
than those based on concurrently assessed placebo effects, primarily becaus
e baseline pain was remembered as being much more intense than it actually
was. However, similar to concurrent placebo effects, remembered placebo eff
ects were strongly associated with expected pain levels that occurred just
after conditioning. Taken together, these results suggest that magnitudes o
f placebo effect are dependent on multiple factors, including conditioning,
expectancy, and whether analgesia is assessed concurrently or Introspectiv
ely. (C) 1999 international Association for the Study of Pain. Published by
Elsevier Science B.V.