Cerebral blood flow velocities in an infant with moyamoya disease

Moyamoya disease is a progressive cerebrovascular disorder with bilateral o cclusion of the basal circulation and development of collateral blood suppl y. In a 6-month-old female with multifocal ischemic infarctions, transcrani al pulsed Doppler sonography revealed extremely high and low cerebral blood flow velocities, dampened waveforms, reversed flow,and musical murmurs, Ma gnetic resonance angiography revealed different degrees of vascular stenosi s and an abnormal collateral network. Moyamoya disease was confirmed by con ventional angiography at the age of 10.5 months. Pulsed-wave transcranial D oppler sonography is a noninvasive screening method in infants at risk of m oyamoya disease. (C) 1999 by Elsevier Science Inc. All rights reserved.