Autonomic nervous system function in childhood migraine

Background: Although the pathogenesis of migraine is controversial, autonom ic nervous system (ANS) dysfunction has been reported in patients with adul t migraine in recent years. The present study was planned to investigate AN S function in childhood migraine. Methods: The migraine and control groups consisted of 25 migraineur and 30 healthy children, respectively. Orthostatic test, sustained handgrip, Valsa lva ratio, 30/15 ratio and heart rate responses to deep breathing were used as non-invasive ANS function tests in both groups. Results: In the orthostatic test, systolic (SBP) and diastolic blood pressu res (DBP) were higher in the upright than the supine position in the migrai ne group, but were higher in the supine than upright position in the contro l group. In the sustained handgrip test, the mean difference in SEP was hig her in the migraine than the control group (P = 0.0278), but there was no s ignificant difference in DBP between migraine and control groups (P = 0.107 ). The Valsalva ratio was higher in the migraine than the control group (P = 0.0002), as was the 30/15 ratio (P = 0.0108). Heart rate responses to dee p breathing were not different between the migraine and control groups (P = 0.749). Conclusions: Our results demonstrate ANS dysfunction, with hyperactivity of both the sympathetic and parasympathetic nervous system, in children with migraine.