Isolation and identification of a peptide and its cDNA from the mosquito Aedes aegypti related to Manduca sexta allatotropin

Authors
Veenstra, JA Costes, L
Citation
Ja. Veenstra et L. Costes, Isolation and identification of a peptide and its cDNA from the mosquito Aedes aegypti related to Manduca sexta allatotropin, PEPTIDES, 20(10), 1999, pp. 1145-1151
Citations number
27
Categorie Soggetti
Biochemistry & Biophysics
Journal title
PEPTIDES
ISSN journal
01969781 → ACNP
Volume
20
Issue
10
Year of publication
1999
Pages
1145 - 1151
Database
ISI
SICI code
0196-9781(199910)20:10<1145:IAIOAP>2.0.ZU;2-S
Abstract
Immunocytochemistry revealed that an allatotropin-immunoreactive peptide is produced by several neuroendocrince cells in the abdominal ganglia of the mosquito Aedes aegypti. The immunoreactive peptide was isolated and its str ucture determined to be Ala-Pro-Phe-Arg-Asn-Ser-Glu-Met-Met-Thr-Ala-Arg-Gly -Phe-amide. A cDNA clone encoding this novel neuropeptide was shown to enco de a single copy of this peptide. The cDNA is unusual in that the first sev en ATGs are not used for translation initiation. (C) 1999 Elsevier Science Inc. All rights reserved.