Affinity capillary electrophoresis in pharmaceutics

The technique of Affinity capillary electrophoresis (ACE) is a useful tool to characterize complexation and partition equilibria. A wide range of appl ications in pharmaceutics has been presented: the determination of pK(A) va lues, of association constants between drugs and cyclodextrins or amphiphil ic compounds as well as the characterization of drug affinities to several vehicle systems, such as micelles, microemulsions and liposomes. Due to the widespread use of capillary electrophoresis in drug analysis, the technica l equipment is quite common. ACE is advantageous as a rapid and simple scre ening method which provides quantitative results about various interactions with a minimum of substance consumption and time spent.