The health and economic benefits of influenza vaccination for healthy and at-risk persons aged 65 to 74 years

Objective: The objective of this study was to assess the health and economi c benefits of influenza vaccination in both healthy and at-risk seniors age d 65 to 74 years. Design and setting: We used administrative claims data from 6 consecutive s erial cohorts spanning the years 1990 to 1991 through 1995 to 1996. All mem bers of a Twin-Cities managed care organisation who were greater than or eq ual to 65 years of age for the respective study year were included in each cohort. Other information obtained included demographic characteristics, ba seline comorbidities, prior resource utilisation, and influenza vaccination status. Study outcomes included hospitalisations for pneumonia and influen za and for all respiratory conditions and death. Economic analyses assumed the societal perspective and included both direct and indirect costs. Main outcome measures and results: During the 6 study seasons, there were 1 00 195 person-periods of observation for persons aged 65 to 74 years. Of th ese, two-thirds were healthy and one-third had at least one major baseline comorbidity. Influenza vaccination was associated with reductions in hospit alisations for pneumonia and influenza and for all respiratory conditions i n both healthy and at-risk groups, although the results did not reach stati stical significance among the healthy individuals. Vaccination was also ass ociated with significant reductions in the risk of death for both groups. T he economic analysis demonstrated that vaccination against influenza in the base case was associated with direct and total cost savings for both healt hy and at-risk seniors aged 65 to 74 years. Conclusion: Influenza vaccination of healthy and at-risk seniors aged 65 to 74 years is associated with substantial health benefits and is cost saving . These findings support age-based vaccination strategies for all persons g reater than or equal to 65 years of age.