Neuroprotective role of curcumin from Curcuma longa on ethanol-induced brain damage

Authors
Rajakrishnan, V Viswanathan, P Rajasekharan, KN Menon, VP
Citation
V. Rajakrishnan et al., Neuroprotective role of curcumin from Curcuma longa on ethanol-induced brain damage, PHYTOTHER R, 13(7), 1999, pp. 571-574
Citations number
31
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHYTOTHERAPY RESEARCH
ISSN journal
0951418X → ACNP
Volume
13
Issue
7
Year of publication
1999
Pages
571 - 574
Database
ISI
SICI code
0951-418X(199911)13:7<571:NROCFC>2.0.ZU;2-7
Abstract
In the present study, curcumin from Curcuma longa was screened for neuropro tective activity using ethanol as a model of brain injury. Oral administrat ion of curcumin to rats caused a significant reversal in lipid peroxidation , brain lipids and produced enhancement of glutathione, a non-enzymic antio xidant in ethanol intoxicated rats, revealing that the antioxidative and hy polipidaemic action of curcumin is responsible for its protective role agai nst ethanol induced brain injury. Copyright (C) 1999 John Wiley & Sons, Ltd .