Effects of extract of Cistus populifolius L. on the central nervous system

We report the effects on the central nervous system (CNS) and on analgesic activity of an aqueous extract of Cistus populifolius L. The extract was as sayed for effects on spontaneous locomotor activity, methylphenidate-induce d hypermotility, motor coordination, exploratory behaviour, rectal temperat ure and sodium pentobarbital-induced hypnosis. Analgesic activity was evalu ated using the hot plate test. The C. populifolius extract at dosages of 28 6 and 430 mg/kg caused very significant reductions in spontaneous locomotor activity, hypermotility, motor coordination, exploratory behaviour and rec tal temperature, and a slight increase of sleeping time was noted in the so dium pentobarbital-induced sleep test. The extract exhibited central analge sic affects in the hot plate test, Copyright (C) 1999 John Wiley & Sons, Lt d.