Antiviral and anticoagulant activities of a water-soluble fraction of the marine diatom Haslea ostrearia

Authors
Berge, JP Bourgougnon, N Alban, S Pojer, F Billaudel, S Chermann, JC Robert, JM Franz, G
Citation
Jp. Berge et al., Antiviral and anticoagulant activities of a water-soluble fraction of the marine diatom Haslea ostrearia, PLANTA MED, 65(7), 1999, pp. 604-609
Citations number
27
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
65
Issue
7
Year of publication
1999
Pages
604 - 609
Database
ISI
SICI code
0032-0943(199910)65:7<604:AAAAOA>2.0.ZU;2-F
Abstract
A water-soluble fraction from the marine diatom Haslea ostrearia was capabl e to inhibit the in vitro replication of HSV-1 in Veto cells with 50 % inhi bitory concentration (EC50) of 14 mu g/ml at a multiplicity of infection of 0.01 ID50/cells. In addition, this fraction delayed the HIV-l-induced sync itia formation on MT4 cells. At:concentrations up to 200 mu g/ml, no cytoto xicity was observed for both the Vero and MT4 cells. The fraction only inhi bited the blood coagulation process at concentrations considerably exceedin g the EC50.