Platelet aggregation in atopic dermatitis

Many observations suggest the active role of platelets in allergic inflamma tion. However, this problem is poorly researched in atopic dermatitis, The aim of study was to examine the intensity and velocity of platelet aggregat ion and a potential relationship with some immunological parameters (total IgE and specific-IgE serum levels) in atopic dermatitis patients. Platelet aggregation was evaluated in 12 subjects with atopic dermatitis and 12 heal thy, nonatopic persons, according to the Born method, in a dual-channel agg regometer, in response to three exogenous stimulators (ADP, thrombin and co llagen). The intensity and velocity of platelet aggregation and total plate let counts did not differ between the two groups irrespective of the type o f extrinsic stimulator used. In contrast to other atopic diseases, in atopi c dermatitis platelet aggregation is not impaired.