Combined low-dose-rate brachytherapy and external beam radiation for cervical cancer: Experience over ten years

Cervical cancer was treated with a combination of external beam and intraca vitary radiation during a 10-year period at Wayne State University. Data we re collected for 216 patients treated radically with external beam radiatio n (EBRT) and low-dose-rate brachytherapy for cervical cancer between 1980 a nd 1991 at Wayne State University. Patient distribution by stage was IB, 20 .8%; IIA, 7.4%; IIB, 26.9%; IIIA, 1.8%; IIIB, 40.7%; and TVA, 2.3%. Surviva l curves were constructed using Kaplan-Meier methods and differences betwee n groups were tested for significance using the log-rank test. Multivariate analysis was done using the Cox proportional hazards model. With a median follow-up of 114 months, actuarial disease-free survival for all patients w as 60% at 5 years and 55% at 10 years. Actuarial 5-year survival for Stage IB was 79%; for Stage II, 59%; and for Stage III, 53%. There were 14/216 (6 %) of patients with severe late complications. On univariate analysis, race was found to be statistically significant, with Caucasian patients having better survival than African American (P = 0.03). The survival for patients treated in shorter overall times was significantly higher (P < 0.001), esp ecially with treatment completion in under 58 days. The stepwise Cox multiv ariate analysis provided the following significant results: race (African A merican vs. Caucasian; P = 0.04, RR = 1.6), Stage (II vs. I, P = 0.004, RR = 2.6), Stage (III vs. I; P = 0.004, RR = 2.5), and overall treatment time (P = 0.006, RR = 1.62). Rates of local control, survival, and complications among women treated with combined external beam and intracavitary radiatio n for cervix cancer were similar to those of prior retrospective studies. ( C) 1999 Wiley-Liss, Inc.