Non-traumatic so-called spontaneous intracerebral hemorrhages can occur in
the supra- and infratentorial compartment. Taking into account their differ
ent etiologies, hemorrhages within the cerebral hemispheres are commonly di
vided into two categories, deep and lobar ones, with the first ones being f
requently related to hypertensive vasculopathy. Lobar hemorrhages that are
usually larger than their counterparts in the basal ganglia or thalamus, ma
y be associated with arterio-venous malformations, leukemia or, especially
in the elderly, with cerebral amyloid angiopathy (CAA) that is histopatholo
gically characterized by deposits of beta A4-protein exclusively within the
walls of medium-sized and small arteries of the leptomeninges and cerebral
cortex.