Class II-independent generation of CD4 memory T cells from effecters

The factors required for the generation of memory CD4 T cells remain unclea r, and whether there is a continuing requirement for antigen stimulation is critical to design of vaccine strategies. CD4 effecters generated in vitro from naive CD4 T cells of mice efficiently gave rise to small resting memo ry cells after transfer to class II-deficient hosts, indicating no requirem ent for further antigen or class ii recognition.