This paper considers linear models with misspecification of the form f(x) =
E(y\x) = Sigma(j=1)(p) theta(j)g(j)(x) + h(x), where h(x) is an unknown fu
nction. We assume that the true response function f comes from a reproducin
g kernel Hilbert space and the estimates of the parameters theta(j) are obt
ained by the standard least squares method. A sharp upper bound for the mea
n squared error is found in terms of the norm of h. This upper bound is use
d to choose a design that is robust against the model bias. It is shown tha
t the continuous uniform design on the experimental region is the all-bias
design. The numerical results of several examples show that all-bias design
s perform well when some model bias is present in low dimensional cases.