The first synthesis of the bis(indole) marine alkaloid caulersin

Authors
Fresneda, PM Molina, P Saez, MA
Citation
Pm. Fresneda et al., The first synthesis of the bis(indole) marine alkaloid caulersin, SYNLETT, (10), 1999, pp. 1651-1653
Citations number
23
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
10
Year of publication
1999
Pages
1651 - 1653
Database
ISI
SICI code
0936-5214(199910):10<1651:TFSOTB>2.0.ZU;2-Y
Abstract
The first synthesis (seven steps) of the bis(indole) marine alkaloid cauler sin is described. Construction of the central seven-membered ring is based on a Michael-type addition of the appropriate 2,3'-bis(indolyl)ketone to me thylvinylketone followed by intramolecular nucleophilic substitution of the resulting 3-oxoalkylated product.