Pyrazole, pyridine and pyridone synthesis on solid support

Authors
Grosche, P Holtzel, A Walk, TB Trautwein, AW Jung, G
Citation
P. Grosche et al., Pyrazole, pyridine and pyridone synthesis on solid support, SYNTHESIS-S, (11), 1999, pp. 1961-1970
Citations number
31
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
11
Year of publication
1999
Pages
1961 - 1970
Database
ISI
SICI code
0039-7881(199911):11<1961:PPAPSO>2.0.ZU;2-Z
Abstract
Versatile solid-phase syntheses of trisubstituted pyrazole carboxylic acids , trisubstituted pyridines and disubstituted pyridones are presented. Pyraz oles are prepared by reaction of polymer bound arylidene- or alkylidene-bet a-oxo esters with phenylhydrazines. Pyridines result from the Krohnke react ion of immobilised enones with 1-(2-oxo-2-arylethyl)pyridinium salts and am monium acetate. Pyridones are obtained from polymer bound enones, 1-(methox y-carbonylmethyl)pyridinium bromide and ammonium acetate.