Use of tetrabenzo[a,c,g,i]fluorene as an anchor group for the solid/solution phase synthesis of the quinolone antibacterial, ciprofloxacin

The affinity of tetrabenzo[a,c,g, i]fluorene (Tbf) for charcoal has been ap plied successfully to provide an alternative to existing solid phase synthe sis methodology. In a synthesis of the quinolone antibacterial, Ciprofloxac in, traditional solution phase synthesis has been coupled with efficient ps eudo-solid phase purification.