The development of a solid phase Tsuge reaction and its application in high throughput robotic synthesis

Authors
Brooking, P Crawshaw, M Hird, NW Jones, C MacLachlan, WS Readshaw, SA Wilding, S
Citation
P. Brooking et al., The development of a solid phase Tsuge reaction and its application in high throughput robotic synthesis, SYNTHESIS-S, (11), 1999, pp. 1986-1992
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
11
Year of publication
1999
Pages
1986 - 1992
Database
ISI
SICI code
0039-7881(199911):11<1986:TDOASP>2.0.ZU;2-A
Abstract
A multicomponent solid phase Tsuge reaction has been developed for automate d synthesis. A production protocol satisfying the requirements of high thro ughput synthesis (960 compounds/week) is described. Isoxazole-fused tetrahy droindolizines 7 were produced as mixtures of diastereoisomers, generally i n a >9:1 ratio.