Yv. Bilokin et al., A novel and expedient approach to new heterocycles containing benzothiophene, benzothieno[2,3-d] pyrimidine and coumarin moieties, TETRAHEDRON, 55(48), 1999, pp. 13757-13766
In order to obtain potent protein-tyrosine kinase inhibitors, a novel and v
ersatile method for synthesis of heterocyclic compounds 4a-d and 5a-c compr
ising 2-imino-2H-1-benzopyran, tetrahydrobenzo[b]thiophene, and carboxamide
/1H-benzimidazole fragments has been developed. This method was based on th
e reactions of 2-imino-2H-1-benzopyrans 1a,b and 2 with 2-amino-4,5,6,7-tet
rahydrobenzo[b]thiophenes 3a-c in glacial acetic acid. Furthermore, new het
erocycles 8a,b with tetrahydrobenzo[4,5]thieno[2,3-d] pyrimidine and coumar
in moieties have been synthesized via a rearrangement of the corresponding
2-(tetrahydrobenzo[b]thien-2-yl)imino-2H-1-benzopyran-3-carboxamides 4a,b.
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