Dissociation constants of carboxylic acids by C-13-NMR in DMSO/water

Authors
McDonagh, AF Phimister, A Boiadjiev, SE Lightner, DA
Citation
Af. Mcdonagh et al., Dissociation constants of carboxylic acids by C-13-NMR in DMSO/water, TETRAHEDR L, 40(49), 1999, pp. 8515-8518
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
49
Year of publication
1999
Pages
8515 - 8518
Database
ISI
SICI code
0040-4039(199912)40:49<8515:DCOCAB>2.0.ZU;2-M
Abstract
Measurements on eighteen (COOH)-C-13-labeled acids, including hydrogen-bond ed and non-hydrogen-bonded standards are self-consistent and suggest strong ly that the aqueous pK(a)s of bilirubin are within the normal range for ali phatic carboxylic acids. Our empirical observations provide further evidenc e that the C-13-NMR method is valid when suitable buffers, DMSO concentrati ons and extrapolations are used and refute recent suggestions to the contra ry. (C) 1999 Elsevier Science Ltd. All rights reserved.