Copper(I) reactions in N-heterocycle synthesis: efficient preparation of substituted pyrrolidinones

Authors
Davies, DT Kapur, N Parsons, AF
Citation
Dt. Davies et al., Copper(I) reactions in N-heterocycle synthesis: efficient preparation of substituted pyrrolidinones, TETRAHEDR L, 40(49), 1999, pp. 8615-8618
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
49
Year of publication
1999
Pages
8615 - 8618
Database
ISI
SICI code
0040-4039(199912)40:49<8615:CRINSE>2.0.ZU;2-Y
Abstract
Reaction of halo-enamides with copper(I) chloride in boiling toluene has be en shown to produce unsaturated pyrrolidinones in excellent yield (81-94%). Both di- and trichloroamide precursors can be used to form dienes via an i nitial 5-endo-trig radical cyclisation. (C) 1999 Elsevier Science Ltd. All rights reserved.