H. Challa et Sa. Woski, Incorporation and characterization of abasic and phenyl residues in peptide nucleic acids, TETRAHEDR L, 40(48), 1999, pp. 8333-8336
The N-(2-aminoethyl)glycine backbone unit of PNA has been derivatized with
phenylacetic acid and acetic acid moieties to produce monomers for incorpor
ation into PNAs. As expected, oligomers containing these residues form PNA-
DNA double helices that are destabilized compared to the unsubstituted dupl
exes. However, unlike the analogous substitutions in DNA, these residues sh
ow very little sequence specificity. (C) 1999 Elsevier Science Ltd. All rig
hts reserved.