Incorporation and characterization of abasic and phenyl residues in peptide nucleic acids

Authors
Challa, H Woski, SA
Citation
H. Challa et Sa. Woski, Incorporation and characterization of abasic and phenyl residues in peptide nucleic acids, TETRAHEDR L, 40(48), 1999, pp. 8333-8336
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
48
Year of publication
1999
Pages
8333 - 8336
Database
ISI
SICI code
0040-4039(19991126)40:48<8333:IACOAA>2.0.ZU;2-N
Abstract
The N-(2-aminoethyl)glycine backbone unit of PNA has been derivatized with phenylacetic acid and acetic acid moieties to produce monomers for incorpor ation into PNAs. As expected, oligomers containing these residues form PNA- DNA double helices that are destabilized compared to the unsubstituted dupl exes. However, unlike the analogous substitutions in DNA, these residues sh ow very little sequence specificity. (C) 1999 Elsevier Science Ltd. All rig hts reserved.