New synthetic approaches to ethyl 3,3-difluoro-2-methylacrylate

Authors
Botteghi, C Paganelli, S Sbrogio, F Zarantonello, C
Citation
C. Botteghi et al., New synthetic approaches to ethyl 3,3-difluoro-2-methylacrylate, TETRAHEDR L, 40(48), 1999, pp. 8435-8437
Citations number
24
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
48
Year of publication
1999
Pages
8435 - 8437
Database
ISI
SICI code
0040-4039(19991126)40:48<8435:NSATE3>2.0.ZU;2-2
Abstract
3,3-Difluoro-2-methylacrylate (DFMA) was synthesized starting from ethyl 2- (trifluoromethyl) propanoate according to two different preparative routes with yields ranging from 70 to 90%. Alternatively, DFMA was obtained from e thyl pyruvate by Wittig reaction using the difluoromethylentriphenyl phosph orane ylide. (C) 1999 Published by Elsevier Science Ltd. All rights reserve d.