Bisphosphonate prodrugs: a new synthetic strategy to tetraacyloxymethyl esters of methylenebisphosphonates

Authors
Vepsalainen, JJ
Citation
Jj. Vepsalainen, Bisphosphonate prodrugs: a new synthetic strategy to tetraacyloxymethyl esters of methylenebisphosphonates, TETRAHEDR L, 40(48), 1999, pp. 8491-8493
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
48
Year of publication
1999
Pages
8491 - 8493
Database
ISI
SICI code
0040-4039(19991126)40:48<8491:BPANSS>2.0.ZU;2-C
Abstract
A concise and simple method to prepare Cl2C[P(O)(OCH2O2CCMe3)(2)](2) starti ng from H2C[P(O)(OMe)(2)](2) with high selectivity and reasonable yield is developed; (C) 1999 Elsevier Science Ltd. All rights reserved.