The PH superfold: a structural scaffold for multiple functions

Pleckstrin homology (PH) domains form a structurally conserved family that is associated with many regulatory pathways within the cell. Domains with a nearly identical fold are found in other families that share no Sequence s imilarity, suggesting the existence of a stable PH superfold. The PH domain s generally function as regulated membrane-binding modules that bind to ino sitol lipids and respond to upstream signals by targeting the host proteins to the correct cellular sites. The other domains with a similar fold, such as the phosphotyrosine binding domains, recognize protein ligands.