Creation and formation of the shape of matter

Citation
T. Sakai et al., Creation and formation of the shape of matter, YAKUGAKU ZA, 119(11), 1999, pp. 805-821
Citations number
17
Categorie Soggetti
Pharmacology & Toxicology
Journal title
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
ISSN journal
00316903 → ACNP
Volume
119
Issue
11
Year of publication
1999
Pages
805 - 821
Database
ISI
SICI code
0031-6903(199911)119:11<805:CAFOTS>2.0.ZU;2-2
Abstract
When matter assembles to take a shape, there arises a function specific to the shape, and at the same time the value is produced. A shape of matter or iginates from physics of the constituents combined with the environmental c onditions holding the matter. It is convenient for recognition of shape to classify the matter in three categories; non-living matter, living organic matter and man-made matter. In the case of non-living matter, a process of shape arrangement is clearly understood by means of thermodynamics. It is also distinctly recognized th at, in total stabilizing energy of the shape Delta G degrees, the entropy t erm T Delta S degrees is responsible for the shape creation. Shape arrangem ent often proceeds through kinetic regime, in such cases (Delta G degrees)( not equal) or T(Delta S degrees)(not equal) should be adopted. Synthetical formation of the shape can of course be attained thermodynamically or kinet ically. In the case of living organic matter, the creation of the shape depends on evolution, which is undoubtedly based on environmental conditions as well a s physical properties of the matter itself A key compound in shape arrangem ent of living organic matter is a globular protein. For the formation of th e shape of the globular protein, nature uses chaperone while human beings u tilize a refolding technique known as an important down-stream art of the r ecombinant DNA process. Detailed description of the art appears in a text a s the course to achieve the quantitative refolding of several globular prot eins. The shape of man-made matter keeps the successive creation via evolution op erated by the market economics. Formation of the shape is managed skillfull y by means of mechanical engineering and/or material sciences. In the last section, some aspects on the possibility of a man-made enzyme are described .