Histopathological analysis of endometrial hyperplasia and stage Ia adenocarcinoma

It has been reported that endometrial hyperplasia is a precancerous lesion of endometrial carcinoma and FIGO stage Ia endometrial carcinoma is believe d as the earliest stage of endometrial adenocarcinoma. The objective of thi s paper is to clarify the pathological features of endometrial hyperplasia and stage Ia endometrial carcinoma. Forty-five patients with stage Ia endom etrial carcinoma who underwent surgical therapy and 86 with endometrial hyp erplasia who underwent dilatation and curettage were placed for the study. It is concluded that stage Ia endometrial carcinoma usually associated with endometrial hyperplasia and carcinoma is adjacent frequently with endometr ial hyperplasia especially complex atypical one. Simple hyperplasia occurre d from the proliferative endometrium under the condition of unopposed estro gen and subsequently changed to complex hyperplasia and complex atypical hy perplasia and complex atypical hyperplasia is the precursor to endometrial hyperplasia.