Endometrial carcinoma: one disease?

It has been reported that endometrial carcinoma has two pathogenetic types; one with and the other without endometrial hyperplasia Present study is to clarify whether this is true in our series of patients with endometrial ca rcinoma or not. One hundred and eighty-two patients (63.0%) were classified as group 1 and 107 (37.0%) as group 2. Younger patients, carcinoma with myometrial invasio n less than 1/3, surgical stage I, endometrioid adenocarcinoma or adenoacan thoma, lower grade carcinoma and progesterone receptor level were significa ntly higher in group 1 than in group 2. The cumulative survival rate for st age I was significantly higher in group 1. Incidences of group 1 patients w ith endometrioid carcinoma or adenoacanthoma were higher in early carcinoma or borderline lesion reaching 100%. A typical hyperplasia localized adjace nt to stage Ia carcinomain 91.2%.