Effects of retinoic acid on the production of transforming growth factor-beta isoforms in human ovarian adenocarcinoma cell line in vitro

Authors
Chao, KC Chang, CC Yeng, MS Twu, NF
Citation
Kc. Chao et al., Effects of retinoic acid on the production of transforming growth factor-beta isoforms in human ovarian adenocarcinoma cell line in vitro, 7TH BIENNIAL MEETING OF THE INTERNATIONAL GYNECOLOGIC CANCER SOCIETY, 1999, pp. 191-196
Citations number
14
Categorie Soggetti
Current Book Contents
Journal title
7TH BIENNIAL MEETING OF THE INTERNATIONAL GYNECOLOGIC CANCER SOCIETY → ACNP
Year of publication
1999
Pages
191 - 196
Database
ISI
SICI code
Abstract
We studied the effects of differential agent retinoic acid on the expressio n of the transforming growth factor-beta isoforms in cultured OC-117-VGH ov arian cancer cells. Treatment of OC-117-VGH cells with retinoic acid for 16 hrs did not reduced cellular proliferation but reduced the expression of t he transforming growth factor-beta isoforms. Determination of expression of the transforming growth factor-beta isoforms by enzyme-linked immunosorben t assay (ELISA) revealed that the transforming growth factor-beta isoforms expression were reduced by 15%similar to 25%. Our results showed the import ant role of retinoic acid in the expression of the transforming growth fact or-beta isoforms in ovarian cancer cells.