Long term follow-up of 58 patients with sex cord stromal tumors

Fifty-eight cases of Sex Cord Stromal Tumors were studied. These neoplasms are detected characteristically at an early stage and they may recur locall y years after the initial diagnosis. In our series the most frequent cell t ype was Adult Granulosa Cell Tumor (70.7%); a total of 34 patients (58.6%) had stage IA lesions. Uterine adenocarcinoma and endometrial hyperplasia we re found in 13.8% and 5.2% of cases respectively. Among the 34 stage TA, 8 (23.5%) underwent conservative surgery whereas a definitive surgery was per formed in the remaining 26 (76.5%). Adjuvant chemotherapy (VAC-PVB or FEB) vas administered to 5/34 (14.7%) stage IA and to 21/24 (87.5%) patients wit h more advanced disease. The actuarial 5-year survival rate is 90.7% in sta ge I-II and 12.5% in stage III-IV. Two out of 5 patients with recurrent dis ease, who had received combined surgery and chemotherapy as a salvage treat ment, survived.