Phase II multicentric trial of neoadjuvant Bleomycin, Ifosfamide and Carboplatin (BIC) in locally advanced cervical cancer

Authors
Murad, AM Triginelli, SA
Citation
Am. Murad et Sa. Triginelli, Phase II multicentric trial of neoadjuvant Bleomycin, Ifosfamide and Carboplatin (BIC) in locally advanced cervical cancer, 7TH BIENNIAL MEETING OF THE INTERNATIONAL GYNECOLOGIC CANCER SOCIETY, 1999, pp. 421-425
Citations number
8
Categorie Soggetti
Current Book Contents
Journal title
7TH BIENNIAL MEETING OF THE INTERNATIONAL GYNECOLOGIC CANCER SOCIETY → ACNP
Year of publication
1999
Pages
421 - 425
Database
ISI
SICI code
Abstract
In this phase II multicentric trial the combination of bleomycin, ifosfamid e and carboplatin was used to treat neoadjuvantly 24 patients with locally advanced squamous cell carcinoma of the cervix. We observed 75% of objectiv e responses (OR). All 18 responders went to surgery: 16 attained substantia l tumor regression and had a potentially curative surgery. Three patients a ttained complete response (CR) pathologically documented: no tumor was foun d in the surgical specimen. The 45-month relapse-free survival is 75%. CT w as very well tolerated. Accrual onto this study continues.