Super high dose CDDP intra-arterial infusion chemotherapy with percutaneous pelvic perfusion under extracorporeal chemo-filtration circuit for locally advanced cervical carcinoma

Authors
Takeuchi, S Hamana, S Tateiwa, Y Miyahara, Y Motoyama, S Ku, E Maruo, T
Citation
S. Takeuchi et al., Super high dose CDDP intra-arterial infusion chemotherapy with percutaneous pelvic perfusion under extracorporeal chemo-filtration circuit for locally advanced cervical carcinoma, 7TH BIENNIAL MEETING OF THE INTERNATIONAL GYNECOLOGIC CANCER SOCIETY, 1999, pp. 479-484
Citations number
5
Categorie Soggetti
Current Book Contents
Journal title
7TH BIENNIAL MEETING OF THE INTERNATIONAL GYNECOLOGIC CANCER SOCIETY → ACNP
Year of publication
1999
Pages
479 - 484
Database
ISI
SICI code
Abstract
As a management of locally advanced cervical carcinoma with stage IIIB and IVA, a super high dose (140-240 mg/m(2)/course) infusion with percutaneous pelvic perfusion with chemo-filtration was performed for 18 patients (pts) and the efficacy was evaluated. This procedure was performed twice before s urgery and/or radiotherapy. Fifteen out of 18 pts were evaluable. The avera ge absorption rate of free-Pt was 84.2%. Adverse effects of CDDP were minim al. Response was 100% (2CR+13PR/15) and pathological CR was obtained in two cases. Overall survival rate was 73.3%. It seems that using this neo-adjuv ant chemotherapy the outcome of patients with this locally advanced disease will be improved.