Impacts of added progestogen on biochemical markers of the bone turnover undergoing hormone replacement therapy in Korean postmenopausal women

The purpose of this study was to evaluate the impact of added progestogen o n biochemical markers of the bone turnover undergoing hormone replacement t herapy (HRT) in the postmenopausal women. There are 71 postmenopausal women who are divided into three groups. Group I is given estrogen (conjugated e quine estrogen; GEE, 0.625mg, day 1-30) plus progestogen (medroxyprogestero ne acetate; MPA 2.5 mg, day 1-30), Group II is given estrogen (CEE, 0.625mg , day 1-30) only, Group III is given estrogen (CEE, 0.625mg, day 1-30) plus progestogen (MPA, 5mg, day 1-12). After 12 months of HRT it was found that there was no significance in decreases in biochemical markers among three groups (P>0.05). We concluded that progestogen was not impact on decreasing on the biochemical markers of bone turnover in postmenopausal women underg oing HRT.