Endogenous/exogenous estrogens & satiety plus appetite stimulating peptides in women

Data how sex hormones can modulate food intake and how relate to obesity ar e missing. In our study we try to evaluate effects of the endogenous and ex ogenous estradiol on plasma satiety and appetite stimulating peptides in pr e (n=31) and postmenopausal women (n=30) obese (BMI>30.0 kg/m(2)) and nonob ese. Serum FSH levels was correlated with appetite stimulating peptides - p ositively with serum galanin (p<0.007) and negatively (p<0.004) with NPY le vels (p=0.005), but estradiol was positively correlated (p<0.006) with sati ety peptide-cholecystocinine (CCK). In hysterectomized women (n=8) only ser um CCK levels increase significantly from 40.5+/-8.3 pg/ml to 62.6+/-9.1 pg /ml after three months of estrogens replacement therapy. Our results may su ggest a possible influence of endo- and exogenous estrogens in climacteric women on CCK, which therefore can modulate food intake.