Possible preventative agents for endometrial carcinoma

Short- and long-term experiments in mice were conducted to examine the effe cts of medroxyprogesterone acetate (MPA), danazol, tamoxifen (TAM), toremif en (TOR), Glycyrrhizae radix (G1 radix) extract, glycyrrhizin (GL) and Juze n-taiho-to on mouse endometrial carcinogenesis. MPA, danazol, TOR, G1 radix , GL and Juzen-taiho-to treatments decreased the levels of c-fos/jun mRNA a nd their oncoproteins. Meanwhile, TAM-treatment increased their expressions . Using endometrial carcinogenesis models, the above chemicals were examine d for 30 weeks. MPA, danazol, TOR, G1 radix, GL and Juzen-taiho-to treatmen ts showed inhibitory effects on endometrial carcinogenesis, meanwhile TAM s howed enhancing effects.