Progestin effect on blood pressure during combination with transdermal estradiol - chlormadinone acetate versus norethisterone acetate

To evaluate the effect of chlormadinone acetate (CMA) 2 mg/d or norethister one acetate 1 mg/d sequentially combined with continuous or cyclical transd ermal estradiol 0.05 mg/d (ETTS) on blood pressure (BP), 416 peri- and post menopausal women were treated in an open prospective 4-months study. Mean a ge, weight, height and menopausal status were comparable in all 4 subgroups . Between groups as well as within groups analysis showed no statistical di fferences in BP during monthly measurements. Thus sequential CMA or NETA ha s no negative impact on BP in normotensive climacteric women when combined with transdermal estradiol replacement, although in risk patients the effec t may not be predicted.