Regulation of dosage of conjugated equine estrogen in add-back therapy foruterine myoma and menopausal symptoms

Authors
Hoshimoto, K Mityuya, K Enomoto, H Hayashi, M Ohkura, T
Citation
K. Hoshimoto et al., Regulation of dosage of conjugated equine estrogen in add-back therapy foruterine myoma and menopausal symptoms, 9TH INTERNATIONAL MENOPAUSE SOCIETY WORLD CONGRESS ON THE MENOPAUSE, 1999, pp. 189-193
Citations number
3
Categorie Soggetti
Current Book Contents
Journal title
9TH INTERNATIONAL MENOPAUSE SOCIETY WORLD CONGRESS ON THE MENOPAUSE → ACNP
Year of publication
1999
Pages
189 - 193
Database
ISI
SICI code
Abstract
It is difficult to keep serum estradiol (E-2) levels in therapeutic window (TW) by administering 0.625 mg conjugated equine estrogen (CEE) either dail y or every other day in add-back therapy for uterine myoma. The aim of this study is to regulate the dosage of CEE to keep serum E-2 levels in TW and to evaluate improvement in postmenopausal symptoms induced by GnRH analog. In 78% of patients, the regulation of dosage of CEE granules kept E-2 level s in TW and our method of add-back therapy was also effective for the impro vement in postmenopausal symptoms.