Perimenopausal TNF alpha serum levels parallel with atherosclerosis, arterial hypertension and ageing

Aim: An estimation of serum TNF alpha level relations in perimenopausal wom en arterial blood pressure, total cholesterol, triglicerydes, DHEAS, testos terone levels. Material & Methods.: Serum TNF alpha, DHEAS, total cholester ol and triglicerydes levels as well as arterial pressure were assessed in g roup of 90 perimenopausal women. Results: In 21 women older than 55 years t he serum TNF alpha: levels correlate with age, total cholesterol and trigli cerydes. In 27 hypercholesterolemic women the serum TNF alpha correlated wi th age, FSH, total cholesterol and triglicerydes. In 28 obese women TNF alp ha correlated with serum FSH levels and negatively with 17 beta-estradiol, estrone and estriol. In the group of 16 hypertensive women the direct corre lations between TNF alpha levels and age, FSH, prolactin and triglicerydes were found. With serum DHEAS level below 120 ng/ml (n=33) serum TNF-alpha l evels revealed direct correlation with age, total cholesterol and triglicer ydes. In 38 postmenopausal women TNF alpha refers to triglicerydes, testost erone and indirect IGFBP-3 so as f-T4. Conclusion: In peri and postmenopaus al women the serum TNF-alpha levels seem to parallel progression of such pr ocesses as atherosclerosis, arterial hypertension, obesity and ageing.