C. Yasunaga et al., Effects of a parathyroidectomy on the immune system and nutritional condition in chronic dialysis patients with secondary hyperparathyroidism, AM J SURG, 178(4), 1999, pp. 332-336
BACKGROUND: Parathyroid hormone (PTH) has an adverse effect on the immune s
ystem and may cause immunologic disorders in patients with chronic renal fa
ilure. The in vivo effects of a parathyroidectomy on the immunologic parame
ters was examined.
METHODS: Thirty-four patients under dialysis therapy received a parathyroid
ectomy (PTx) for secondary hyperparathyroidism (HPT). They were prospective
ly studied regarding serum immunoglobulins, complements, CD markers, and se
rum soluble IL-2 receptor (sIL-2R) until 12 months after PTx.
RESULTS: The serum levels of IgG, IgA and IgM showed significant increase u
ntil 12 months after PTx (P <0.001, respectively). C3, C4, and CH50 also in
dicated significant increase at 12 months after PTx. In cellular immunity,
only serum sIL-2R showed significant increase 2 weeks after PTx (P = 0.028)
. The hematocrit and serum albumin also improved significantly at 12 months
.
CONCLUSIONS: PTx showed beneficial effects on humoral immunological markers
. The effects are probably due to the remarkable PTH reduction and partly i
mproved nutritional state after PTx. (C) 1999 by Excerpta Medica, Inc.