Spitz tumors in children - A grading system for risk stratification

Objective: To describe a grading system for risk stratification of atypical Spitz tumors in children and adolescents. In some circumstances, unequivoc al distinction between Spitz nevus and melanoma is practically impossible. It is likely that these lesions for which we lack specific diagnostic crite ria represent a broad histological continuum extending from benign to malig nant tumors. Therefore, we propose that Spitz tumors be categorized into lo w-, intermediate-, or high-risk categories based on the accumulation of abn ormal features. Design: Retrospective study. Settings: Institutional practice. Patients: We present 30 cases of atypical Spitz tumors in patients younger than 18 years evaluated for at least 3 years or in whom a metastatic event developed during this period. Intervention: None. Main Outcome Measure: The grading system was formulated after data collecti on. Results: Among the parameters studied, only diagnosis at age greater than 1 0 years, diameter of the lesion greater than 10 mm, presence of ulceration, involvement of the subcutaneous fat (level V), and mitotic activity of at least 6/mm(2) carried a likelihood ratio greater than 1.50 and were therefo re used for the grading system. Conclusion: The application of an objective grading system, such as the one described herein for the first time, is the first step in providing useful information for the management of atypical Spitz tumors.