LDL size and risk of coronary heart disease in elderly men and women

A predominance of small, dense, low density lipoprotein (LDL) particles has consistently been associated with coronary heart disease (CHD) in young an d middle-aged subjects in cross-sectional studies. Recently, 3 prospective, case-control studies showed that decreased LDL size is a predictor of CHD in middle-aged subjects. However, it is not known whether decreased LDL siz e is mainly associated with premature CHD or whether it continues to play a role in CHD risk at older ages also. We performed a prospective, nested ca se-control study in 86 subjects (58 nondiabetic and 28 type 2 diabetic) age d 65 to 74 years who were free of myocardial infarction at baseline and who then had a myocardial infarction or CHD death during a 3.5-year follow-up (cases) and in 172 controls matched for sex and diabetes status but who rem ained free of CHD during follow-up. LDL particle size determined by gradien t gel electrophoresis (268.2+/-0.9 versus 268.5+/-0.7 Angstrom, P=0.782) an d the proportion of subjects with LDL subclass phenotype B (20.9 versus 21. 5, P=0.914) were similar among cases and controls. Furthermore, diastolic b lood pressure, total cholesterol, high density lipoprotein cholesterol, tri glycerides, apolipoprotein A,, fasting glucose, fasting insulin, waist-to-h ip ratio, and body mass index were not associated with CHD risk. However, s moking and increased systolic blood pressure, apolipoprotein B levels, and the total cholesterol-high density lipoprotein cholesterol ratio were signi ficant predictors of CHD events both in univariate and multivariate analyse s. Our findings indicate that LDL size is not a predictor of CHD events in elderly white subjects after controlling for diabetes status.