C. Minassian et al., Regulatory role of glucose-6 phosphatase in the repletion of liver glycogen during refeeding in fasted rats, BBA-MOL CEL, 1452(2), 1999, pp. 172-178
Citations number
34
Categorie Soggetti
Cell & Developmental Biology
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
We analyzed the biochemical mechanisms involved in the liver glycogen reple
tion upon refeeding for 360 min in 48 and 96 h-fasted rats. In 48 h-fasted
rats, the glycogen synthesis involved a rapid and further sustained inducti
on of glucokinase (GK) (increased twice from 90 min) and a rapid but transi
ent activation of glycogen synthase a (GSa) (maximal increase by 150% at 90
min). It did not involve the inhibition of glycogen phosphorylase a (GPa).
In 96 h-fasted rats, the glycogen repletion did not involve the induction
of GK for the first 180 min of refeeding. It involved a slow activation of
GSa (maximal 150% increase at 180 min) and a rapid inhibition of cpa (signi
ficant from 90 min, maximal 50% inhibition by 180 min). In both groups of r
ats, there was a progressive inhibition of the glucose-6 phosphatase (Glc6P
ase) activity (maximal suppression by 30% in both groups at 360 min). These
results highlighted a key role for the inhibition of Glc6Pase activity in
the liver glycogen repletion upon refeeding. (C) 1999 Elsevier Science B.V.
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