Protective role of intraperitoneally administered vitamins C and E and selenium on the levels of lipid peroxidation in the lens of rats made diabeticwith streptozotocin
M. Naziroglu et al., Protective role of intraperitoneally administered vitamins C and E and selenium on the levels of lipid peroxidation in the lens of rats made diabeticwith streptozotocin, BIOL TR EL, 70(3), 1999, pp. 223-232
The aim of this work was to determine the protective effects of intraperito
neally administered vitamins C and E and selenium on the lipid peroxidation
(MDA), glutathione peroxidase (GSH-Px), reduced glutathione (rGSH) activit
ies in the lens of rats induced diabetic with streptozotocin (STZ). Lenses
in the diabetic control group had a slightly higher mean level of MDA compa
red with lenses of the vitamin E and selenium groups, although the mean lev
els of MDA were significantly lower in control, combination, and vitamin C
groups than in the diabetic control group (p < 0.05 and p < 0.01). However,
MDA levels were significantly lower in vitamin C, vitamin E, and combinati
on groups than in controls (p < 0.01).
The GSH-Px activities of lenses were significantly higher in vitamin C-, vi
tamin E- and selenium-injected groups than that in the diabetic control gro
up (p < 0.01), whereas, the activity of GSH-Px was significantly lower in t
he diabetic control group than in the control group. Ln addition, the rGSH
content was seen to decrease only in the vitamin C group compared to both c
ontrol and diabetic control groups (p < 0.05).
In conclusion, the results from these experiments indicate that vitamins C
and E and selenium can protect the lens against oxidative damage, but the e
ffect of vitamin C appears to be much greater than that of vitamin E and se
lenium.