EDTA chelation therapy does not selectively increase chromium losses

Chelation therapy and supplemental Cr have both been shown to lead to impro ved blood glucose, lipids, and insulin activity. Chelation therapy leads to the removal of toxic as well as essential metals. To determine if chelatio n therapy leads to increased urinary Cr losses and altered Cr homeostasis, 2 groups of subjects (1 group that had undergone only 1 or no chelation the rapy and 1 group in which all subjects had undergone at least 19 chelation sessions) were evaluated for differences in possible Cr homeostasis based o n urinary Cr losses. There were no significant differences in urinary Cr lo sses between the two groups of subjects and there were no significant incre ases in urinary Cr losses resulting from chelation therapy. Increases in ur inary Cr losses were strongly influenced by supplementation but not chelati on therapy.