Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under

Authors
Kizu, J Arakawa, M Arakawa, Y Komoda, F Takamizawa, M Iwata, T Hayakawa, T Imai, K
Citation
J. Kizu et al., Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under, BIOMED CHRO, 13(7), 1999, pp. 462-464
Citations number
6
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOMEDICAL CHROMATOGRAPHY
ISSN journal
02693879 → ACNP
Volume
13
Issue
7
Year of publication
1999
Pages
462 - 464
Database
ISI
SICI code
0269-3879(199911)13:7<462:ETMIPW>2.0.ZU;2-K
Abstract
The plasma levels of theophylline (TP) and its metabolites were measured in patients with bronchial asthma who were treated with a slow-release prepar ation of TP. The ratios of the plasma levels of these metabolites to TP lev els in the group aged 1-4 years were larger than those in the group aged 5 years and older, suggesting enhanced activity of drug-metabolizing enzymes during infancy. Copyright (C) 1999 John Wiley & Sons, Ltd.