Development of predictive retention-activity relationship models of antipsychotic drugs by micellar liquid chromatography

The predictive and interpretative capability of quantitative chromatographi c retention-biological activity models is supported by the fact that in ade quate experimental conditions the solute partitioning into the chromatograp hic system can emulate the solute partitioning into lipid bilayers of biolo gical membranes, which is the basis of drug and metabolite uptake, passive transport across membranes and bioaocumulation. The use of micellar solutio ns of Brij35 as mobile phases in reversed Liquid chromatography has proven to be valid in predicting some biological activities of different kinds of drugs. In this paper, the correlations between the logarithm of capacity fa ctors and pharmacokinetic, preclinical pharmacology and therapeutic efficac y parameters of phenothiazines are studied. Parabolic quantitative retentio n-activity relationship models with predictive and interpretative ability h ave been obtained. Copyright (C) 1999 John Wiley & Sons, Ltd.